Estudios clínicos

The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model – a cross-over study

The plaque inhibitory effect of a CPC mouthrinse in a 3-day plaque accumulation model – a cross-over study
Autores: PA Versteeg, NAM Rosema, NL Hoenderdos, DE Slot, GA Van der Weijden
Publicado en: International Journal of Dental Hygiene
Más info: http://www.ncbi.nlm.nih.gov/pubmed/20961382

DESCRIPCIÓN

Abstract: 

Objective: 

To test the plaque inhibitory effect of an experimental 0.07% cetylpyridinium chloride (CPC) mouthrinse in a 3-day plaque accumulation model in a cross- over design. 

Material and Methods: 

A total of 30 subjects (non-dental students), 18 years of age, were randomly assigned to use one of three different mouthrinses three times a day. After 3 days, the subjects returned for the clinical assessments and received a questionnaire to evaluate their attitude towards the product used by them. The cross-over procedure was repeated twice to have all subjects use all products. 

Results: 

A total of 29 subjects completed the protocol and this resulted in a statistically significant difference between the three groups (P < 0.001) with regard to plaque scores. Over three sessions, the mean plaque scores were 2.17 for the control product, 1.14 for the CPC group and 1.12 for the 0.1% Hexetidine product (positive control). Results of the questionnaire show that, compared with hexetidine, the taste of the CPC was appreciated better, and less oral sensations were observed following rinsing. 

Conclusion:

The CPC mouthrinse proved to be effective in inhibiting ‘de novo’ plaque formation to an extent similar to that of a 0.1% hexetidine product. Compared with hexetidine, the taste of the CPC was appreciated better and less oral sensations were observed following rinsing.

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