Estudios clínicos

Effects of gustatory stimulants of salivary secretion on salivary pH and flow: a randomized controlled trial

Effects of gustatory stimulants of salivary secretion on salivary pH and flow: a randomized controlled trial
Autores: ADSP da Mata, DN da Silva Marques, JML Silveira, JROF Marques, ET de Melo Campos Felino, NFRPM Guilherme
Publicado en: Oral Diseases (2009)
Más info: http://www.ncbi.nlm.nih.gov/pubmed/19220764

DESCRIPCIÓN

OBJECTIVES: 

To compare salivary pH changes and stimulation efficacy of two different gustatory stimulants of salivary secretion (GSSS).

SETTING: 

Portuguese Dental Faculty Clinic. 

DESIGN: 

Double blind randomized controlled trial. SUBJECTS: One hundred and twenty volunteers were randomized to two intervention groups. Sample sized was calculated using an alpha error of 0.05 and a beta of 0.20. 

MATERIALS AND METHODS: 

Participants were ran- domly assigned to receive a new gustatory stimulant of secretory secretion containing a weaker malic acid, fluoride and xylitol or a traditionally citric acid-based one. Saliva collection was obtained by established methods at different times. The salivary pH of the samples was determined with a pH meter and a microelectrode. 

MAIN OUTCOME MEASURES: 

Salivary pH variations and counts of subjects with pH below 5.5 for over 1 min and stimulated salivary flow were the main outcome measures. 

RESULTS: 

Both GSSS significantly stimulated salivary output without significant differences between the two groups. The new gustatory stimulant of salivary secretion presented a risk reduction of 80 ± 10.6% (95% CI) when compared with the traditional one. 

CONCLUSIONS: 

Gustatory stimulants of salivary secretion with fluoride, xylitol and lower acid content maintain similar salivary stimulation capacity while reducing significantly the dental erosion predictive potential.

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