Estudios clínicos

Effectiveness of malic acid 1% in patients with xerostomia induced by antihypertensive drugs

Autores: Gerardo Gómez-Moreno, Javier Guardia, Antonio Aguilar-Salvatierra, Maribel Cabrera-Ayala, José- Eduardo Maté-Sánchez de-Val, José-Luis Calvo-Guirado
Publicado en: Med Oral Patol Oral Cir Bucal. 2013
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Assessing the clinical effectiveness of a topical sialogogue on spray (malic acid, 1%) in the treatment of xerostomia induced by antihypertensive drugs. 

Study Design: 

This research has been carried out through a randomized double-blind clinical trial. 45 patients suffer- ing from hypertensive drugs-induced xerostomia were divided into 2 groups: the first group (25 patients) received a topical sialogogue on spray (malic acid, 1%) whereas the second group (20 patients) received a placebo. Both of them were administered on demand for 2 weeks. Dry Mouth Questionnaire (DMQ) was used in order to evaluate xeros- tomia levels before and after product/placebo application. Unstimulated and stimulated salivary flows rates, before and after application, were measured. All the statistical analyses were performed by using SPSS software v17.0. Dif- ferent DMQ scores at the earliest and final stage of the trial were analysed by using Mann-Whitney U test, whereas Student’s T-test was used to analyse salivary flows. Critical p-value was established at p<0.05.


DMQ scores increased significantly (clinical recovery) from 1.21 to 3.36 points (p<0.05) after malic acid (1%) application whereas DMQ scores increased from 1.18 to 1.34 points (p>0.05) after placebo application. After two weeks of treatment with malic acid, unstimulated salivary flow increased from 0.17 to 0.242 mL/min whereas

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