Estudios clínicos

Effect of different chlorhexidine formulations in mouthrinses on de novo plaque formation

Effect of different chlorhexidine formulations in mouthrinses on de novo plaque formation
Autores: Quirynen M, Avontroodt P, Peeters W, Pauwels M, Coucke W, Van Steenberghe
Publicado en: Journal of Clinical Periodontology (2001)
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Background: Chlorhexidine (CHX) 0.2% solution, still the golden standard as mouthrinse for the prevention of plaque formation and development of gingi- vitis, has some limited side-effects such as extrinsic tooth staining, poor taste, taste disturbance, sensitivity changes in tongue, pain, and the content of alco- hol. These side effects led to the search of new formulations.


In this double-blind, randomised, cross-over study, 16 young dental students with a healthy periodontium, abolished all means of mechanical plaque control during 4 experimental periods of 11 days (separated from each other by a washout period of 3 weeks). During each experimental period, they rinsed 2¿ daily with one of the following mouthrinses in a randomised order: CHX 0.2% π alcohol (CorsodylA), CHX 0.12% π alcohol (Perio.AidA), CHX 0.12% π so- dium fluoride 0.05% (Cariax GingivalA) and CHX 0.12% π CPC 0.05% (Per- io.AidA, new formulation). After 7 and 11 days of undisturbed plaque forma- tion, clinical parameters were recorded, questionnaires completed and plaque samples (supragingivally and saliva) collected.


The CHX 0.12% π alcohol and the CHX 0.12% π CPC 0.05% formu- lations were as efficient as the CHX 0.2% mouthrinse in retarding de novo plaque formation (proven by clinical observations as well as by anaerobic and aerobic culture data), and always superior (p


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