Estudios clínicos

A 0.05% cetyl pyridinium chloride/ 0.05% chlorhexidine mouth rinse during maintenance phase after initial periodontal therapy

DESCRIPCIÓN

Background: 

Chlorhexidine (CHX) mouth rinse/spray can still be considered the gold standard in the chemical prevention of plaque formation and development of gingivitis. The product unfortunately has some side effects, such as extrinsic tooth staining, poor taste, taste disturbance, sensitivity changes in tongue, pain and irritation because of the alcohol content. These side effects led to the search of new formulations.

Methods: 

In this double-blind, randomized, long-term, parallel study, 48 moderate periodontitis patients rinsed for 6 months (starting immediately after a ‘‘one-stage, full-mouth’’ disinfection) with one of the following products: CHX 0.2%1alcohol s (Corsodyl ), CHX 0.05% 1 cetyl pyridinium chloride (CPC) 0.05% and no alcohol (Perio-Aid Maintenance , a new formulation), or the placebo of the latter. After 1, 3 and 6 months a series of clinical and microbiological parameters were recorded for the supra- and subgingival area as well as for saliva.

Results: 

Although there was a significant treatment impact (mechanical debridement) in all groups, both CHX solutions further decreased both plaque and gingivitis indices (po0.001 and po0.05, respectively), when compared with placebo. This was also reflected by additional reductions in the number of CFU/ml of aerobic and especially anaerobic species and by a suppression of Streptococcus mutans (versus an overgrowth for the placebo), in all niches. Differences between both CHX solutions were never encountered. The subjective ratings were slightly in favour of the new CHX–CPC formulation when compared with the other CHX–alcohol formulation, especially for taste of the product (po0.05), but less impressive for the staining of teeth and tongue.

Conclusions: 

The results of this study demonstrated the potential of a new CHX 0.05%1CPC 0.05% non-alcoholic formulation as an effective antiplaque agent for long-term use with reduced subjective side effects.

ETIQUETAS

Volver al listado de estudios
¡NO TE PIERDAS
NINGÚN CURSO!

Apúntate al sistema de alertas y estarás al día de las últimas actualizaciones

ESTUDIOS RELACIONADOS

  • Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults
    Más info
  • The efficacy of a topical sialogogue spray containing 1% malic acid in patients with antidepressant-induced dry mouth: a double-blind, randomized clinical trial.
    Más info
  • Eficacia del spray de ácido málico 1% (Xeros Dentaid spray©) en el tratamiento de la xerostomía inducida por fármacos
    Más info

¿TE PODEMOS AYUDAR?  
Envía tu consulta y pronto uno de nuestros especialistas se pondrá en contacto contigo.